| Target：/strong> | MPO |
| Fields： | >>Drug metabolism - other enzymes;>>Phagosome;>>Neutrophil extracellular trap formation;>>Transcriptional misregulation in cancer;>>Acute myeloid leukemia |
| Gene Name： | MPO |
| Protein Name： | Myeloperoxidase(MPO) |
| Human Gene Id： | 4353 |
| Human Swiss Prot No： | >P05164 |
| Immunogen： | Synthesized peptide derived from human Myeloperoxidase(MPO) |
| Specificity： | This antibody detects endogenous levels of human Myeloperoxidase(MPO). Heat-induced epitope retrieval (HIER) Citrate buffer of pH6.0 was highly recommended as antigen repair method in paraffin section |
| Formulation： | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source： | Monoclonal, Mouse/IgG2a, Kappa |
| Dilution： | IHC-p 1:100-500. IF 1:50-200 |
| Purification： | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Storage Stability： | -20°C/1 year |
| Background： | Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014], |
| Function： | catalytic activity:Cl(-) + H(2)O(2) = HOCl + 2 H(2)O.,catalytic activity:Donor + H(2)O(2) = oxidized donor + 2 H(2)O.,cofactor:Binds 1 calcium ion per heterodimer.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer.,disease:Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.,function:Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.,online information:MPO mutation db,online information:Myeloperoxidase entry,similarity:Belongs to the peroxidase family. XPO sub |
| Subcellular Location： | Lysosome. |
| Expression： | Leukemia,Leukocyte,Liver,Plasma,Saliva, |