| Gene name: | FCGR3B(CD16B;FCG3;FCGR3;IGFR3); |
| Protein name:Alternative: CD: | Low affinity immunoglobulin gamma Fc region receptor III-B; IgG Fc receptor III-1;Fc-gamma RIII-beta(Fc-gamma RIII;Fc-gamma RIIIb;FcRIII;FcRIIIb);FcR-10; CD16b; |
| Organism: | Human (Homo sapiens). |
| Sub Unit: | Monomer. Interacts with INPP5D/SHIP1. |
| Function: | Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. |
| Subcellular Location: | Cell membrane Lipid-anchor GPI-anchor Secreted Secreted after cleavage. |
| Sequence length: | 233 |
| Sequence: | |
| 50: | MWQLLLPTAL | LLLVSAGMRT | EDLPKAVVFL | EPQWYSVLEK | DSVTLKCQGA | |
| 100: | YSPEDNSTQW | FHNESLISSQ | ASSYFIDAAT | VNDSGEYRCQ | TNLSTLSDPV | |
| 150: | QLEVHIGWLL | LQAPRWVFKE | EDPIHLRCHS | WKNTALHKVT | YLQNGKDRKY | |
| 200: | FHHNSDFHIP | KATLKDSGSY | FCRGLVGSKN | VSSETVNITI | TQGLAVSTIS | |
| 233: | SFSPPGYQVS | FCLVMVLLFA | VDTGLYFSVK | TNI |
| 3D Structure: | N/A |
| UniGene: | Hs.372679 |
| STRING: | 9606.ENSP00000294800 |
| MIM: | 610665 |
| KEGG: | hsa:2215 |
| SMR: | O75015 |
| UniGene: | Hs.694258 |
| String: | O75015 |
| Uniprot: | O75015 |