| Gene name: | Parp2(Adprt2;Adprtl2;Aspartl2); |
| Protein name: | Poly [ADP-ribose] polymerase 2(PARP-2;mPARP-2); |
| Alternative: | Poly[ADP-ribose] synthase 2(pADPRT-2);NAD(+) ADP-ribosyltransferase 2(ADPRT-2);Poly[ADP-ribose] synthase 2(pADPRT-2); |
| Organism: | Mouse (Mus musculus). |
| Sub Unit: | Component of a base excision repair (BER) complex, containing at least XRCC1, PARP1, POLB and LRIG3. Homo- and heterodimer with PARP1. |
| Function: | Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. |
| Subcellular Location: | Nucleus |
| Sequence length: | 559 |
| Sequence: | |
| 50: | MAPRRQRSGS | GRRVLNEAKK | VDNGNKATED | DSPPGKKMRT | CQRKGPMAGG | |
| 100: | KDADRTKDNR | DSVKTLLLKG | KAPVDPECAA | KLGKAHVYCE | GDDVYDVMLN | |
| 150: | QTNLQFNNNK | YYLIQLLEDD | AQRNFSVWMR | WGRVGKTGQH | SLVTCSGDLN | |
| 200: | KAKEIFQKKF | LDKTKNNWED | RENFEKVPGK | YDMLQMDYAA | STQDESKTKE | |
| 250: | EETLKPESQL | DLRVQELLKL | ICNVQTMEEM | MIEMKYDTKR | APLGKLTVAQ | |
| 300: | IKAGYQSLKK | IEDCIRAGQH | GRALVEACNE | FYTRIPHDFG | LSIPPVIRTE | |
| 350: | KELSDKVKLL | EALGDIEIAL | KLVKSERQGL | EHPLDQHYRN | LHCALRPLDH | |
| 400: | ESNEFKVISQ | YLQSTHAPTH | KDYTMTLLDV | FEVEKEGEKE | AFREDLPNRM | |
| 450: | LLWHGSRLSN | WVGILSHGLR | VAPPEAPITG | YMFGKGIYFA | DMSSKSANYC | |
| 500: | FASRLKNTGL | LLLSEVALGQ | CNELLEANPK | AQGLLRGKHS | TKGMGKMAPS | |
| 550: | PAHFITLNGS | TVPLGPASDT | GILNPEGYTL | NYNEFIVYSP | NQVRMRYLLK | |
| 559: | IQFNFLQLW |
| 3D Structure: | N/A |
| SMR: | O88554 |
| KEGG: | mmu:11546 |
| String: | O88554 |
| Pfam: | PF00644 |
| UniGene: | Mm.281482 |
| STRING: | 10090.ENSMUSP00000048877 |
| Uniprot: | O88554 |