| Gene name: | PARP2(ADPRT2;ADPRTL2); |
| Protein name: | Poly [ADP-ribose] polymerase 2(PARP-2;hPARP-2); |
| Alternative: | Poly[ADP-ribose] synthase 2(pADPRT-2);NAD(+) ADP-ribosyltransferase 2(ADPRT-2);Poly[ADP-ribose] synthase 2(pADPRT-2); |
| Organism: | Human (Homo sapiens). |
| Sub Unit: | Component of a base excision repair (BER) complex, containing at least XRCC1, PARP1, POLB and LRIG3. Homo- and heterodimer with PARP1. |
| Function: | Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. |
| Subcellular Location: | Nucleus |
| Sequence length: | 583 |
| Sequence: | |
| 50: | MAARRRRSTG | GGRARALNES | KRVNNGNTAP | EDSSPAKKTR | RCQRQESKKM | |
| 100: | PVAGGKANKD | RTEDKQDGMP | GRSWASKRVS | ESVKALLLKG | KAPVDPECTA | |
| 150: | KVGKAHVYCE | GNDVYDVMLN | QTNLQFNNNK | YYLIQLLEDD | AQRNFSVWMR | |
| 200: | WGRVGKMGQH | SLVACSGNLN | KAKEIFQKKF | LDKTKNNWED | REKFEKVPGK | |
| 250: | YDMLQMDYAT | NTQDEEETKK | EESLKSPLKP | ESQLDLRVQE | LIKLICNVQA | |
| 300: | MEEMMMEMKY | NTKKAPLGKL | TVAQIKAGYQ | SLKKIEDCIR | AGQHGRALME | |
| 350: | ACNEFYTRIP | HDFGLRTPPL | IRTQKELSEK | IQLLEALGDI | EIAIKLVKTE | |
| 400: | LQSPEHPLDQ | HYRNLHCALR | PLDHESYEFK | VISQYLQSTH | APTHSDYTMT | |
| 450: | LLDLFEVEKD | GEKEAFREDL | HNRMLLWHGS | RMSNWVGILS | HGLRIAPPEA | |
| 500: | PITGYMFGKG | IYFADMSSKS | ANYCFASRLK | NTGLLLLSEV | ALGQCNELLE | |
| 550: | ANPKAEGLLQ | GKHSTKGLGK | MAPSSAHFVT | LNGSTVPLGP | ASDTGILNPD | |
| 583: | GYTLNYNEYI | VYNPNQVRMR | YLLKVQFNFL | QLW |
| 3D Structure: | N/A |
| MIM: | 607725 |
| Pfam: | PF00644 |
| String: | Q9UGN5 |
| KEGG: | hsa:10038 |
| UniGene: | Hs.409412 |
| SMR: | Q9UGN5 |
| STRING: | 9606.ENSP00000250416 |
| Uniprot: | Q9UGN5 |